My husband and I stayed four nights in Room 42, a double with private terrace, for 235 Euros/night (cash rate 215/Euros). This was our second stay at this small hotel (ten rooms) and again we had a great experience. Room 42 consists of one average-sized king bedroom, a modern, pretty bath, and a surprisingly large terrace (about 10X12 feet, estimate) with a table, two chairs and potted plants along the ledge. Can't say the view from the terrace was attractive (residential rooftops), but we had our own private, pleasant happy hours there with wine, bread and olives purchased at a wonderful little grocery steps down the Via Coronari. There is a small refrigerator in the room.
Residenza Canali is located along the Via Coronari, a quiet, pretty, historic street of antique shops less than one block from (and pleasantly removed from) the noisy Piazza Navona. This is a lovely, safe area in Rome. One can walk to the Pantheon in less than five minutes, Castel San Angelo in ten, the Vatican in twenty minutes. The buses along Via Zanardelli, a block away, take you to the Forum, the Coloseum, Termini, etc. in just minutes You can purchase multi-day bus/metro passes at the tobacco shop at the corner of V. Coronari and V. Zanardelli . (FYI, a bus inspector checked passengers' tickets on one of our trips, and I believe there is a hefty fine if one doesn't have a ticket).
The front desk is staffed by the famous Stefano and Francesca, who are very professional and detail-oriented and have a can-do attitude. They will help you with any need, but the rooms are so comfortable and thoughtfully provisioned, you will likely not need anything other than recommendations for restaurants and such. Cleanliness, nice fabrics, unobtrusive maid service, a lovely breakfast, great location, free internet computer in the lobby, no noise from other rooms, no odors, and proximity to good restaurants made this a perfect choice for us. The hotel has an arrangement with a private limo service to transport you to the airport, no matter how early, for 40 Euros (or 50, can't remember which)...we had a very pleasant young man as our driver.
As for negatives, the stairs and the small shower are all I can think of.
There is a wonderful family-owned small restaurant next door to the hotel, the Ristorante Tre Archi di Loneti. Mr. Loneti is the owner and server. We ate three dinners there (and had on our previous trip to Rome also). The eggplant parmigiana and spinach were wonderful; I looked forward to them all day! The house wine is very good and all prices are reasonable...probably about 45 Euros for two dinners with wine/beer.
If you are looking for a quiet, comfortable, centrally-located small B&B, this is a good choice for you.

Nice little place with personal feel to it. Clean and refurbished rooms with character.
Very central but in a nice and laid back area, just 500 meters from Piazza Navona.

This place was such a pleasant surprise! We stayed for 4 nights, booked with the owner directly via email, were offered a special rate for paying cash.
It's a small B&B, only a few rooms (I think 10 or so) spread over several floors. No elevator, have to climb the stairs, so anyone who is suffering from problems with their legs/feet, might find this a problem. When you enter, have to take the stairs to the 2nd flr where you find the reception, the lounge with computer desk, and the breakfast room. The guest rooms are spread over the floors above.
The location is fantastic, very central, walking distance to anywhere we wished to go in Rome. I especially liked that it's just a few steps from piazza Navona, yet tucked away on a quiet little street.
They have different size rooms. Our first night we were placed in a tiny little room (I think probably a single), but were told upfront that the 1st night we'll spend in a small room, but for the next 3 night we'll be upgraded to a suite. And just as promised, the rest of our stay was spent in a huge 2-room suite, we felt guilty even taking up all that space. We spent very little time in our suite anyway, there's so much to do and see in Rome.
The staff was extremely nice, everyone did their best to make our stay pleasant and comfortable. The breakfast was a decent selection continental-style. We asked for espresso/cappucino, and they were happy to make it for us.
They have a desktop with internet connection for the guests' use, which we found a great convenience.
All in all, great little hotel, extremely good value, I highly recommend it to other travellers.

I decided 2 surprise my new husbend 4 his birthday and take him 2 a 5 day trip in romantic rome.
Since he is useally the plan-maker between the 2 of us, i was a bit afraid to orgnize it all by myself, but thanks to "tripadvisor" it was much easier...
i chose the "residenza canali" especially because of it's location - in the haert of rome, a minute from "piazza navona". it was importent for me that these 5 days will not waste because of travelling by bus and trains.
lucky me, when i contected Francessca by mail, she offerd us the junior suite for my husbend's b-day and for a very reasonble price (90 euro per night in cash).
we were abseloutly not dissapointed when we got 2 the hotel. it's a small cute hotel in walking distence from everywhere in rome ! (vatican - 15 min', piazza venezia- 30 min', fontana di trevi-15 min'...) if you don't want to walk, a lot of bus stations on the main street (zenadrelli i think).
the staff at the hotel were very nice (especially steffano) though a little bit unhelpfull with advises about transportation (i think they just walk most of the time) but it wasn't hard to mannage by ourselvs.
our romm was lovely - big and well decorated, and though we had 2 clime 3 stories everytime - we didn't care (we needed the good shape anyway so we can go around rome by foot). the breakfast is very good also if it's important for you (no vegtebals by the way).
all and all, we had a gr8 time in rome, loved the "residenza canali" and will come back, we hope, with our kids... :)

p.s. - the location of the hotel gave us the opretunity to come back at noon, rest a bit and go out again afternoon. and another tip - around piazza navona is a gr8 area to dring, eat and mix with the locals.