We stayed in room 114 for 3 nights in September. The hotel was easy to find as we discovered you could get a hotel shuttle service from the airport straight to the hotel for €15, one euro more than getting a train to Termini.
The hotel is fairly well located, about a 12 minute walk from the colosseum. On the whole the location wasn't too bad, I wouldn't call central but neither out of the way. For most of the trip we ended up using the metro (about a 8 minute walk away) which meant we could easily get to sights quicker than by foot. This was really easy to use, it's just like the underground in London.
The hotel room was wonderful, very classy and just what is expect from an Italian hotel. The bathroom was really big and it included towels and a hair dryer. The room also came with a TV. Air con was additional (and essential) and wi if was free.
The service on the whole was very good, the only thing was the receptionist told us we had to wear 'proper shoes' to go the the Vatican (as well as covered shoulders and skirts below the knee). I can verify you can wear sandals, which was to my surprise when I got the Vatican.
The only thing I would fault this place on is breakfast- it's very poor. Basically you get a nicely laid table with three bread buns on a place. You then go to a main table where you can have pre-packed croissants, rye bread and more bread rolls. Basically, bread is coming out of your ears!! That said, there was a wide variety of accompaniments- such as butter, jams, cheese spread and chocolate spread.
Drinks were out of a machine, unfortunately the day I went the latte option only produced hot milk :/
On a positive note, for the money, the hotel room was excellent and it's location was fair. It's massively worth noting that there is an amazing hotel parlour only a few doors up which is open till late. It's not expensive and has amazing ice creams. Wish I could have brought it home!!
In a nutshell, avoid breakfast (unless you like to eat only bread) and enjoy your stay!
Get a tour guide to go around the Vatican, we paid €34 after knocking salesman down in price.
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This review is the subjective opinion of a TripAdvisor member and not of TripAdvisor LLC.