We stayed in the Hotel Villa Morgagni for four nights in July before moving on to Florence. We booked using 'Expedia'.
The hotel is situated quite far out from the city of Rome. However, it is very close to a tube station which does give speedy access to the centre. We took the tram into central Rome a couple of nights. There are a couple of lovely restaurants just a few stops away from the hotel and the area was safe to walk through at night.
The hotel itself is very nice with friendly staff. Our room was extremely small, but well presented and very clean. The shower room was tiny, but again clean with plenty of towels and toilettries. Breakfast was served on the roof terrace and there was a very good variety of foods available.
Although this is a good hotel I would not stay in it again due to location.
We had a lovely time in Rome and visited all the usual sights-Vatican, Colloseum, Trevi Fountain, etc. Tip if first time visiting Rome-do not purchase a 'Roma Pass' unless you are intending to visit many museums (as it offers very little else). It doesn't even allow entry into the Vatican Museum.

The Villa Morgagni is very well located: you have to walk only 2 minutes (300 m) from the metro station Policlinico (Line B) to the hotel. The location is very safe; we were strolling in the area late at night and there was nothing which would let us feel in danger. The hotel has 4 floors, whereas the 4th floor is the terrace where you are served breakfast. The room was nice and very clean (small, but not tiny). The air conditioning is a must if you are in Rome during summer and this hotel offers it in every room. The staff is very friendly and helpful. I asked the receptionist to make me a reservation for the Galleria Borghese and it was no problem (the only way to do ONLY a reservation for the Galleria Borghese is by phone!). The breakfast (served between 7.00 and 10.30) here is fantastic, we were really pleasantly surprised by the variety offered to us. There is also a turkish bath in the underground, but you have to pay for it.
A small disadvantage is the fact that the nearest metro station (Policlinico) is served by the Line B and you'll have to change at Termini to Line A to get to almost all tourist attractions (except the Colosseum which on the track of Line B). This will cost you some time and energy and you will not want to be very often in the Termini station because it smells badly and you're risking to get pickpocketed.
Another downside is that you have to pay (4 Euros/hour) to use their computer in the lobby (though they offer WiFi in your room if you bring your notebook, I believe).
If you are looking for a supermarket in Rome (in case you want to pay 1.60 for a 1,5 L coke instead of 4-5 Euros in the center), you'll encounter some serious trouble, because there are almost none or very hard to find if you don't know exactly where to go (at least in August).
Here are some we found along the way:

1) Near Pantheon on Via Giustiana
2) On some small street which ends in Piazza Navona
3) http://www.supermercatigs.it for GS Supermarkets

Me and my husband stayed here for five nights in July. We wanted something at a reasonable price, not to faraway from the city. We payed about a total of 350 euro for the whole stay.

Room
The room we got was small and with a tiny bathroom. When we first enter the room it smelled a bit funky (every day), almost like mold, but that smell disappered fast, I guess we got used to it. But I sneezed a lot during our stay.

Aircondition in room was great.

The room is very old-fashioned decorated with like paisley-cloth and stuff. Bed was comfy. Cleaning good.

We found no hotelinformation on the room, like how much the minibar costed and so on. The TV did not work properly.

Breakfast
Breakfast was good, on the terrace with fresh fruit, cereal, eggs, lots of sweets, yoghurts. You could also get great italian coffee if you asked the staff! =)

Reception
The staff at the reception was ok. They did there job but not really much more. No queues at checking in or out.

Surroundings
The area around the hotel is kind of boring. We found no shops etc. But there is a great little pizza-place nearby where you can buy great, cheap pizza.

The hotel is really close both to buses and Metro, just 2-3 minutes away. Two metro-stops from Termini (centralstation), where you have to switch if you're going to everywhere else but the Colosseum. It's easy to travel by Metro, Rome only has two lines.

So, location is quite good for being in the outskirts, and we were pleased with the cost. But we felt like we got what we payed for, nothing more.

We stayed here for a long weekend and was not disappointed. The hotel was lovely and the room was very nice, big and very well furnished. The breakfast was great and the the roof top terrace is a lovely setting to start the day.
You are situated in a nice quiet area slightly outside of the city centre, but you are only 2 mins from the nearest metro which will get you to the major attractions wihin 5-10 mins. Make sure you get a 3 day metro pass.
Overall this is a lovely hotel with friendly and helpful staff, great value for money and a great place to stay to enjoy Rome.