The Villa Morgagni is very well located: you have to walk only 2 minutes (300 m) from the metro station Policlinico (Line B) to the hotel. The location is very safe; we were strolling in the area late at night and there was nothing which would let us feel in danger. The hotel has 4 floors, whereas the 4th floor is the terrace where you are served breakfast. The room was nice and very clean (small, but not tiny). The air conditioning is a must if you are in Rome during summer and this hotel offers it in every room. The staff is very friendly and helpful. I asked the receptionist to make me a reservation for the Galleria Borghese and it was no problem (the only way to do ONLY a reservation for the Galleria Borghese is by phone!). The breakfast (served between 7.00 and 10.30) here is fantastic, we were really pleasantly surprised by the variety offered to us. There is also a turkish bath in the underground, but you have to pay for it.
A small disadvantage is the fact that the nearest metro station (Policlinico) is served by the Line B and you'll have to change at Termini to Line A to get to almost all tourist attractions (except the Colosseum which on the track of Line B). This will cost you some time and energy and you will not want to be very often in the Termini station because it smells badly and you're risking to get pickpocketed.
Another downside is that you have to pay (4 Euros/hour) to use their computer in the lobby (though they offer WiFi in your room if you bring your notebook, I believe).
If you are looking for a supermarket in Rome (in case you want to pay 1.60 for a 1,5 L coke instead of 4-5 Euros in the center), you'll encounter some serious trouble, because there are almost none or very hard to find if you don't know exactly where to go (at least in August).
Here are some we found along the way:

1) Near Pantheon on Via Giustiana
2) On some small street which ends in Piazza Navona
3) http://www.supermercatigs.it for GS Supermarkets

Me and my husband stayed here for five nights in July. We wanted something at a reasonable price, not to faraway from the city. We payed about a total of 350 euro for the whole stay.

Room
The room we got was small and with a tiny bathroom. When we first enter the room it smelled a bit funky (every day), almost like mold, but that smell disappered fast, I guess we got used to it. But I sneezed a lot during our stay.

Aircondition in room was great.

The room is very old-fashioned decorated with like paisley-cloth and stuff. Bed was comfy. Cleaning good.

We found no hotelinformation on the room, like how much the minibar costed and so on. The TV did not work properly.

Breakfast
Breakfast was good, on the terrace with fresh fruit, cereal, eggs, lots of sweets, yoghurts. You could also get great italian coffee if you asked the staff! =)

Reception
The staff at the reception was ok. They did there job but not really much more. No queues at checking in or out.

Surroundings
The area around the hotel is kind of boring. We found no shops etc. But there is a great little pizza-place nearby where you can buy great, cheap pizza.

The hotel is really close both to buses and Metro, just 2-3 minutes away. Two metro-stops from Termini (centralstation), where you have to switch if you're going to everywhere else but the Colosseum. It's easy to travel by Metro, Rome only has two lines.

So, location is quite good for being in the outskirts, and we were pleased with the cost. But we felt like we got what we payed for, nothing more.

We stayed here for a long weekend and was not disappointed. The hotel was lovely and the room was very nice, big and very well furnished. The breakfast was great and the the roof top terrace is a lovely setting to start the day.
You are situated in a nice quiet area slightly outside of the city centre, but you are only 2 mins from the nearest metro which will get you to the major attractions wihin 5-10 mins. Make sure you get a 3 day metro pass.
Overall this is a lovely hotel with friendly and helpful staff, great value for money and a great place to stay to enjoy Rome.

My husband and I stayed at Villa Morgagni for three nights in May. The location is great -- although it's not in the center of the city, it's right around the corner from the Policlinico metro stop. The metro is cheap, simple to figure out, and essential because Rome sprawls. The staff at Villa Morgagni were helpful and spoke excellent English. We booked a deluxe double room which included a jetted Jacuzzi. After exploring Rome all day, getting into the tub at the end of the day and putting feeling the jets massage my feet made the upgrade worth every penny! The room was nicely furnished with a minibar and flat screen TV, although the only English-language channel was the ever-present CNN World News. My only major gripe was the fact that the our shower water temperature fluctuated MAJORLY during every shower that both my husband and I took. I spent the entire time adjusting the lever so that I would be neither scalding nor freezing cold (and was rather unsuccessful). This made for some rushed and very unenjoyable showers. Breakfast in the morning was great and I really liked the rooftop setting. Overall, a good experience, and I would return here.