We stayed at this hotel in June 2007. I got a good deal through accorhotels.com which turned out to be quite a bit cheaper than most hotels in the main tourist areas. It's a chain hotel but I like this as you usually can expect a certain standard.
The hotel is about 5 minutes walk from Bologna metro station which is only a 3 stops to Termini and 5 to Colloseo so only takes a few minutes to get there. The only downside is that Metro line B stopped at around 10ish so you'd need to get a taxi or bus after this time. There are regular buses from Termini to Plaza Bologna though.
The hotel is contemporary in design and although our room wasn't big, it was adequate for our needs and very clean. The bar area is very small though and is basically just a few seats off reception. We just used it to have a nightcap before heading up to our room.
Breakfast in the hotel was quite good with a selection of hot and cold items, juice, coffee etc and the dining room was never too crowded. I don't think the hotel serves evening meals but we either ate more centrally in Rome or at a couple of local restaurants. If you can cope with going to a place where they only speak Italian (you are in Italy after all), then there's a great little place a couple of streets away. I can't remember the name of it but the hotel reception told us about it. There's also another restaurant between the hotel and the metro (easier found if you walk past the school).
I felt safe in the area surrounding the hotel. There are several shops, selling clothes, bags, food etc just around the corner, and there is a school/kindergarten next door.
I would happily stay at this hotel again as it was easy to get to and from. We got a taxi from Ciampino airport, which cost us double late on a Sunday night so beware of that! However, we did the return journey by metro to Anagnina then got a bus to the airport for a couple of euros....much cheaper, although it can be a bit tricky with suitcases on a packed metro.