We are a couple and stayed for four nights in october. It's definetely a special hotel by its setting: part of a bigger complex still inhabited by monks. It's a quiet location which is a relief after a day of noisy Rome. I do love this kind of setting. It's out of the center and therefore not suitable for a rest during the day. On the other hand the colosseum is still within walking distance. It's close to San Giovanni metro which is convenient.
But we were disappointed expecting a four star hotel. We didn't think it's worth the full price (192 euro a night). We booked the place through a travel agent under the name of Villa Domus. Wish I had known the whole name earlier so I would have booked online more cheap. We never stayed in Rome before though, so I can't compare it with other hotels.
The room was small, no chair, noise from the corridor, and I woke up every morning with an aching back due to the matras.Breakfast was okay. But what put us off, was the lack of service. We needed to print our boarding passes for the way back because we booked with online check-in. They just send us away to a internet-place. I felt like the backpacker I used to be only paying much more than before. Not what you expect a four-star hotel to be.
Overall I would not recommend it.

My sister and I toured Sicily and Rome. We enjoyed this hotel the most. Within walking distance of the Piazza San Giovanni, Collosium, Pantheon, and Forum. 15 minutes by car to Vatican. Close to airport. Hotel clerks were all most helpful and spoke english. Very clean. Saw the Pope perform an open air mass 5-10 minute walk away at San Giovanni Piazza.

Beautiful- Right next to a beautiful church. Character property (was a former monastic dwelling) and yet very modern interior (lifts etc)!! Beautiful view from the roof. Very polite staff. Best breakfast you will get in italy!! Great pastry shop down the road ahead of it. Only down fall was distance from the centre- was a bit difficult to find too!

Fantastic and such a beautiful building!! So much history in that building!

Great location, away from the city center. Two blocks to the train.
Good breakfast, nothing fancy but you won't go away hungry.
Clean room and bathrooms, clean sheets. Uncomfortable beds,
but we were so tired from sightseeing that we slept great.
Friendly and helpful staff. The only problem were the teenagers that hung out in front of the hotel until 2 :00 - 3:00 a.m. They were loud, blasting their music from their scooters everynight.
Hmmm, I thought they only did that in NY or NJ! Other than that it was a great hotel in an excellent location. Two blocks away there are tons of stores and restaurants.