My intention was just to pop into the Vatican museums and the Sistine Chapel to say I'd seen it, but I ended up spending three enjoyable hours being constantly amazed. The Raphael rooms were my highlight, I think more spectacular than the Sistine Chapel.
A couple of points: I advanced booked the museums on the internet, paying a 4 Euro premium to do so. But on arrival at 9.30am the fast-track pre-paid line was longer than the other line! So if you are going at an off-peak time (eg March) I think you will get in ok without pre-booking. (NB this was an individual booking not for a tour).
The museums follow a one-way system, although there are no arrows as such, but to walk against the crowd would be impossible and the wardens don't like you doing this (although I was ok if I was courteous and only walked back when there was a lull). However, from the Sintine Chapel (which is the 'end') you can walk back to the start and go round again. Leave the Sistine Chapel by the left door and keep following the 'exit/library' signs until you reach the spiral ramp down, then rather than walk down the ramp an unsigned gap in the wall will take you back to the start.
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