We recently stayed for two nights at the San Francesco. It's in a great (funky) Greenwich-Village type neighborhood loaded with terrific restaurants and local flavor. We loved the hotel - very clean, comfortable and a great spot. We had only two days and we were able to walk (a couple of miles) to the Vatican one day and the other day walked to the Coliseum, Forum and Palatine Hill. If you don't mind walking on those ancient cobblestone streets its a level walk, although you might find it a bit far to the Vatican, especially walking back! The breakfast at the hotel was lavish by any standard. And, free computer access in the lobby was very helpful. Overall, we'd highly recommend it.
Rooms on the back of the hotel open to a convent garden, which I would expect would be quite a bit quieter with the windows open. We were on the fourth floor and had quite a bit of traffic noise when the windows were open, but you're in a city, so what do you expect!?

Excellent, helpful staff.....the breakfast is lovely with many food item choices. The rooms are very clean. I especially thought the bathrooms were nice, clean, and larger than most. Great location to all the major sites.

We stayed at the Hotel SF on 2 different occasions during our trip to Italy. I found the comments on trip advisor to be very accurate (you never know). Good location, close walking distance to the major sites and numerous trattorias, friendly/helpful staff. The rooms while small by American standards were clean and comfortable and are in line with other hotels we stayed at during the trip.

We stayed at the Hotel San Fracesco for three days in July. The staff was very friendly and helpful. Our flight arrived very early from New York City (7 am) and they gave us our room, which was great because we were so exhausted. The hotel is on the fringe of the Travestere, but all of the sights were relatively close and there are several decent places to eat in the area. The only downside was minimal A/C. It was so hot the last day of our stay we have to leave the mini bar open to cool the room. Not neccessarily a deal breaker (more of a tip!).