We recently stayed for two nights at the San Francesco. It's in a great (funky) Greenwich-Village type neighborhood loaded with terrific restaurants and local flavor. We loved the hotel - very clean, comfortable and a great spot. We had only two days and we were able to walk (a couple of miles) to the Vatican one day and the other day walked to the Coliseum, Forum and Palatine Hill. If you don't mind walking on those ancient cobblestone streets its a level walk, although you might find it a bit far to the Vatican, especially walking back! The breakfast at the hotel was lavish by any standard. And, free computer access in the lobby was very helpful. Overall, we'd highly recommend it.
Rooms on the back of the hotel open to a convent garden, which I would expect would be quite a bit quieter with the windows open. We were on the fourth floor and had quite a bit of traffic noise when the windows were open, but you're in a city, so what do you expect!?
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