The hotel was difficult to find at first - it is on a one-way street and this area of Rome is known for it's maze-lake streets. But other than that, it is actually very centrally located - on three different "trips", we were able to walk (with young children...) to the Pantheon, the Colosseum, and the Vatican in less than 30 minutes. The neighborhood is pretty normal, there is a nice little park behind the hotel where our kids played on the jungle-gym. Now that I think about it, it reminds me a little of a residential neighborhood in New York City, with some businesses, lots of restaurants, lots of apartments, and our little hotel.
We stayed in one of the apartments, which is located in the adjacent building. The service was exceptional, all of the staff spoke English, and the one who checked us in was so proficient, I (wrongly) assumed he was an American. He was able to give us lots of advice about the best ways to go, and had a complimentary map with many of the sights listed on it.
The breakfast was pretty good, with fresh cappuccino or espresso, juices, an assortment of pastries, cereal, bread, and fruits. The apartment was somewhat unusual, but given that it was easily able to accommodate our family of 6, was perfect.
This was everything I wanted in a hotel - I will definitely stay there again when we return to Rome.