We stayed 8 days at the Residenza dei Quiriti and overall had a good experience. Don't let your first impression fool you. We were a little worried when we pulled up to the front of the hotel. It's in a very plain building in a fairly quiet neighborhood about 10 minutes walk to the Vatican. Our worries went away when they showed us to our room. It was in a recently opened, new area of the hotel, on the second floor. The room was modern, clean and had a refrigerator. The king size bed was comfortable and the restroom had a bidet. All in all the room was almost first class. Besides being only 10 minutes from the Vatican, you could walk 20 minutes in the other direction and be at the Piazza dei Popola. From there you had all the shopping and restaraunts you could ask for. Of an evening we would stroll along the Cola dei Rienzo with people from the neighborhood and had a tough choice each night trying to decide where to enjoy dinner.
We only dealt with one employee who spoke english. She was helpful in arranging a day trip to Florence.
This isn't a 5 star hotel so you shouldn't expect it to be. It is a good, clean hotel that is well worth the money. It is in the best possible location for seeing all the sights Rome has to offer. The neighborhood seemed safe and if we go back to Rome we will stay there again.