We felt the deal we got at the Royal Santina was worthwile compared with (atleast the presentation of ) other hotels in the same street.
The Royal Santinas location is right near the back entrance to the termini station (where you can get buses/metro to anywhere) however there were no decent restaurants near the hotel.
Staff we're as straight faced as the majority of Romans we encountered but were pleasant and helpful.
The rooms were cleaned everyday but the halls smelt faintly of cigarettes and there were a few burns/holes in some of the sheets. The bed was uncomfortable but we may have just been unlucky.
We enjoyed the bar and seriously recommend the "pasta and bacon" dish the hotel serve.
As a young couple the hotel offered us everything we expected and provided a good base when we had been out pounding the streets of Rome all day and needed to rest.
All in all, a good hotel experience!

We just stayed at the Royal Santini/Santana in Rome and did not have a very good experience. We stayed in a 'triple' at least that's what we called it. I believe it was their double with a cot. The beds were terrible, actually had a spring poking through one. The cot was even worse. Between the three of us, we were lucky to get 5 hours sleep total! Luckily our travel plans only had us staying there one night, one night too many!! It looked like this was once a nice hotel but it was evident maintenance has not been performed. If in doubt, just take a look at the lobby furniture, we didn't even dare sit on it given its shabby appearance.

The reason we picked this hotel was for its location close to Termini, the rail station since we had an early train to catch to the airport. You'd be better served to find something a little farther from the station and walk ten minutes rather than five. To that, we were surprised how close distances turned out to be as compared to how far we thought they'd be from looking at maps of Rome.

Avoid this place, there's much better to be had. No advantages to staying here.

Don't stay on this hotel! The furniture and the rooms are old, there is a smell of smoke everywhere in the hotel, no matter how much time you leave the windows open. The chief of the restaurant kicks you off it if you arrive near to 10h30m (on a decent hotel, you enter the restaurant and finish the breakfast without being bothered if you arrive before it closes).
The location is nice. However, there is a hundred hotels near the Termini Station in Rome. You can make a better deal staying somewhere else paying probably even less than you would pay for this trash place.

Stayed there many times with my company. Very practical location to be sure, and the comments about the front desk staff are very much to the point, except for a couple of the front desk staff.
The review which mentioned a lost purse/bag caught my interest because two years ago, I mailed work-related materials to the hotel two months ahead of time so they'd be there when I got there; spent two weeks there and never found my stuff. I was back there SEVEN MONTHS later, and asked if by any chance my parcel had ever been received- without even looking the front desl clerk said NO!- I waited till he was busy and looked in the storage room right next to the front desk, and right there on the shelf, in PLAIN VIEW was my parcel. It had actually been there even before my FIRST visit, but no one had ever bothered to check.
The food is pretty basic, but the new ddining room manager is very efficient and very pleasant.
watch out for gypsies & pickpockets hanging around the front doors!!