Don't stay on this hotel! The furniture and the rooms are old, there is a smell of smoke everywhere in the hotel, no matter how much time you leave the windows open. The chief of the restaurant kicks you off it if you arrive near to 10h30m (on a decent hotel, you enter the restaurant and finish the breakfast without being bothered if you arrive before it closes).
The location is nice. However, there is a hundred hotels near the Termini Station in Rome. You can make a better deal staying somewhere else paying probably even less than you would pay for this trash place.

Stayed there many times with my company. Very practical location to be sure, and the comments about the front desk staff are very much to the point, except for a couple of the front desk staff.
The review which mentioned a lost purse/bag caught my interest because two years ago, I mailed work-related materials to the hotel two months ahead of time so they'd be there when I got there; spent two weeks there and never found my stuff. I was back there SEVEN MONTHS later, and asked if by any chance my parcel had ever been received- without even looking the front desl clerk said NO!- I waited till he was busy and looked in the storage room right next to the front desk, and right there on the shelf, in PLAIN VIEW was my parcel. It had actually been there even before my FIRST visit, but no one had ever bothered to check.
The food is pretty basic, but the new ddining room manager is very efficient and very pleasant.
watch out for gypsies & pickpockets hanging around the front doors!!

We have just stayed for a 3 night break at The Royal Santina Hotel and could not fault it. We had a room at the back which meant peace after hitting the streets of Rome.The breakfast was ample, the rooms were clean and comfortable and the staff were all very helpful. We left our luggage in their luggage room on the last day because we had a late flight and we were also able to leave our passports etc in the safe until we picked our luggage up. We would recommend this hotel to anyone , it is convenient to the train and bus stations and all the sightseeing tours of Rome.We were very pleased with the service etc.

went for a short 3 night break to see the sites of Rome and could not have wished for a better hotel, friendly, helpful and ideally situated. Being next to the Termini and bus station thought there might have been a bit of noise, but all was quiet. Would certainly recommend this hotel to friends and family.