We stayed in Cilicia Hotel, for 5 days. Even though the room was on the first floor, facing the road, we had no noise. The room was renovated and very very good. We were surprised because we had selected the hotel for the low rate. Enough space for 2 people, very warm colours, large desk, very good mini bar (sensible prices) and a very big bathroom. We loved it.
I agree that transportation can be a small problem on the first day. The metro station is 20 minutes walking, but it is a pleasant walk, we didn't mind. The only thing was that the line closed early due to constuctions in the station, so coming back was a bid of a problem. There is at least one bus that leaves from Termini station (last one at 00.30) and stops almost in front of the hotel. Taxis on Saturday night is a problem... and due to the traffic it can cost a lot.
The only thing we didn't like much were the receptionists attitude. Not very polite nor helpful. They made us feel as we were bothering them with our questions, and their english, well some of them could use some extra lessons. Anyway we left with the best impressions

Stayed in the Hotel Cilicia, Rome for the second time. The Hotel is located about half a kilometer from San Giovanni in Laterano and is walking distance to the Metro. Location is off a very busy road but set in a garden area. Reception was warm and staff helpful. Got an upstairs room this time (by request). The room was a non smoking room and was large originally well furnished and decorated but needed many small repairs and maintenance. Bed was comfey & the room quiet (courtyard facing) and the bathroom very nicely done in marble. Continental breakfast was average and the food and juice selection was limited. The dining room itself was nice though. Reasonable rate for a three star hotel in Rome. Good value for money but a little out of the way unless you need to be in this part of the city.

Hotel was light and airy and kept very clean was lovely to come back to air con and shower after hot day walking round sights. Staff friendly and helpful no problems. Brekkie fine We took on board prev comments re long walk to metro station Bus is deffo best bet 360 or 228 from via Satrico takes you to San Giovanni metro We also got buses back to the hotel from all areas and attractions in the city no problems either to piazza Zama or via Latina which is just a short walk from hotel There also a lovely walk to San Sebastian Catacoms from hotel passing Quo Vadis a welcome break from the bustle of the city.
Family from Scotland 2 adults 2 teenage kids

Quite nice hotel, very comfortable, clean, renovated and even with a hint of luxury, located inside a small park with lots of greenery & blossom.
Decent brekker, attentive service, pleasantly furnished rooms with all these plush interiors, I even thought of 4* stars level staying there.
However there's one considerable disadvantage - situated far from Rome centre, so no way to reach attractions by feet and to get nearest metro station takes ~25min if walked very quickly.
Means - always check the city maps before agreeing with your travel agency's choice of hotel!