This 5 day trip to Rome was booked back in March 2006 for myself and my mum as a treat. We were highly looking forward to it having never been to Rome before.
We had booked a twin room but on arrival discovered we had been allocated a double bed instead of two singles! We complained to the receptionist but were told that it was the only available room left in the hotel that night and to come back in the morning. The next day we were moved to another room which although did have two single beds, was in appaulling condition. The wallpaper was hanging off the walls, the door was unsecure and it was flithy.
Breakfast was advertised as being of a continental style but we have never had such a lack of choice in any other European hotel we have stayed in. All it consisted of was cups of cornflakes (no bowls in sight!) and awful dry pre packed croissants. The coffee was also disgusting!
The staff were all unhelpfull to us during our stay and non of our concerns were addressed.

We would never stay here again and it should be avoided at all costs!!

Not a bad hotel, not a great hotel. It is officially a 2 star hotel, not 3 as was erroneously mentioned in another review.
Close to major transport hub, but my guess is this would be considered a rather seedy location for some. However, if you planning on going all over, there is a straight shot to anywhere from the nearby Termini Station via bus, tram, taxi or subway. Plus getting to and from the airport is an absolute snap, with practically front door drop off.
While the hand held shower is listed as an amenity, it actually is quite a pain. It would make sense for those with 3 arms, but for us normal folks, it's a bit inconvenient. The problem is that, it is exclusively hand held, i.e. no fixture which means a little bit of carelessness can send the water flow right into you change of clothes and getting clean while managing the shower head can be quite the juggling act.
I'm not sure what they mean by satellite TV since we only had 3 channels. Not really a problem though because you're not in Italy to watch TV.
Some of the staff were quite friendly and others a little grumpy. Tell your friends if they wish to contact you in your hotel room, Italian should be spoken. Otherwise you're liable to get hung up on. Don't expect a lot of English, but rather just enough to get you into your room and perhaps a glass of wine in the cafe.
Though the night clerk will probably be asleep if you get back to your hotel after midnight, don't feel bad about waking him. He will let you in with a smile on his face. The phones have no direct dial to the front desk, so if you forget to leave a wakeup call before bedtime, you either make a local call to the hotel from the line(if you can figure out how to use it), or run down to the front desk in your jammies. If your planning on getting back late, esp. on friday or saturday, prepare for a little "color", as pushy prostitutes and drunken teens will be noticable, if not a complete spectacle.
The included continental breakfast was delightful, and definitely worth getting up early for. They will give you American Coffee(an extreme rarity in Italy) or whip you up an espresso or capuccino if you ask. Italy is not known for inexpensive hotels but all in all, for the traveler at heart, the Hotel Quisisana is completely satisfactory, if a little overpriced. For someone who is used to being pampered and off your toes, you may want to look elsewhere.

We stayed at this 3* hotel for four days the last week of October 2005. We booked it through a Dutch tour operator, so we thought it would be okay. WRONG!! This hotel was in the middle of an on-going refurbishment: hotel doors with the frame work nearly or completely gone, dust and garbage anywhere. As far as amenities go: very small bathroom with mould in the shower curtain, old fashioned and not very well cleaned armatures, very noisy corridors (partly because the locks on the doors are of such a construction as to lock automatically, but with a big BANG! which all the floor may hear), beds are horrible: a very thin mattras which makes you feel all the springs. NO GOOD NIGHT'S REST. We paid to get a breakfast, and we did not expect much when we booked it. We've been to Italy before, and we know they are not good at doing breakfast. At this hotel, breakfast was from 8 til 10. When we got downstairs at 8.30 there were no more fresh rolls. We tell this to the waiter, and all he says: "bread finished". So one had to make do with prepacked pastries and "croisants" with an expiration date of 2008. Yuck! The rest of the "buffet" consisted of a fruit salad and some lemonade passing as juice. That was all. Needless to say, we went out for breakfast and had to spend money for something we already paid for. The thing that really hurt us, is this. The hotel is in close vicinity to Termini railway station, and also close to a museum where we had planned to spend our last hours in Rome, before going back home. We thought to leave the suitcase at the hotel (as you can in ANY HOTEL ALL OVER THE WORLD), walk the two blocks to the museum, see what we wanted to see, pick up our suitcase and get the 12
o' clock train out to the airport. BIG MISTAKE. They refused to take our suitcase, they had a meeting and there was nowhere to keep our luggage. I still feel so angry when I write this down. They ruined our last day because we could not leave the suitcase anywhere. There was a big waiting line at Termini at the dept. to leave luggage, and there was no way of telling if this would last for much longer, and if so what would the situation be when we returned from the museum. We could not risk missing our train. Anyway, we ended up leaving for the airport very early and our last day in beautiful Rome was ruined. This hotel is in the brochures of several Dutch travel organisations and I really think that they let their customers down. We paid GOOD money to stay at this hotel, and it was not worth it. Furthermore, when I read the earlier reviews of this hotel I notice that this refurbishment has been going on since at least 2004! Why on earth do they keep this hotel in their brochures when they know that there is a refurbishment going on. How on earth can this pathetic excuse for a hotel get a 3 star rating? It's a rip-off! DON'T GO HERE! In future I will always check with Tripadvisor before booking a hotel.

Hotel Reservations in the train station told us this was the only room left in Rome. They charged 160 euros for a 60 euro room. They made us pay upfront, which should have warned us. I've never stayed in a shabbier place. It was actually scarey. Trim ripped off doors and windows; trash in halls; lightbulbs missing; phone didn't work; dirty curtains and stained bedding; beds were just metal cots with foam rubber mats; air-conditioning did not work and we told them twice, but they just shrugged. This hotel makes Rome seem a scam.