Think it is fine for what it is - a large conference/chain hotel on the outskirts of Rome. Don't expect luxury and you won't be disappointed.
We had no problems with the shuttle - which is a large coach, not a minibus (as we had expected). Clearly a popular hotel with large groups of US tourists, who can take over the public areas, audibly and physically.
Our room was fine - we were put into a junior suite which was clean, spacious and modern.
If time is short though, there probably are better options closer to Rome to save time on the coach, but a good safe choice for a weekend break.
We wandered out to eat - right at the end of the row of shops (it's almost banana shaped, so imagine the opposite end to the hotel) we found a fantastic little Italian Trattoria. Cheap, honest homecooked food that was some of the best we ate all weekend irrespective of price. We were the only non-Italians in there and judging by the steady stream of takeaway pizzas and lasagnes being taken home, we were not alone in appreciating it.

A very clean hotel with very heplful staff. Well priced if you can incorporate a weekend deal. The restaurant was fantastic and so were all of the staff. The free shuttle bus never let us down. (15 mins late one day but the traffic was very bad - elections were on and the Pope was throwing a party in the square...) Couldn't master the air conditioning system but not an expert as I live in Scotland. (What is air conditioning anyway?) Nor could we get a movie on screen. The hotel was a 30 - 40 min ride from the city which went in quite quickly, but the cleanliness and restaurant makes it worthwhile. Exec suite and Junior suites were excellent. No problems in recommending this one to anyone.

While the room was spacious and clean, the air conditioner did not get the job done. It was 105 degrees outside, and after 3 days on a Tuscan farm, we were looking forward to some modern creature comforts. The pillows were so hard, they hurt our ears. There was no sound-proofing, as evidenced by the constant noise of a wedding party on our floor.The food in the Apulia Apulia restaurant was one step above Chef-Boy-Ardee, and the coffee was the worst I have ever had anywhere. The wait staff acted inconvenienced by our presence in the dining room. One of them had his cell phone on and answered it several times during our dinner. It was an overpriced disappointment to the end of a wonderful vacation in Italy.

As others have stated, the Four Points Sheraton is not in the heart of Rome. There is a shuttle that leaves the hotel every 1 1/2 hours so if you do miss the shuttle you do have a problem. We would take the shuttle every morning at either 8:00am or 9:30am and return on the 11:30pm shuttle. The ride takes about 30 to 45 minutes depending on traffic.
If you're looking to save some money and don't mind being outside Rome, I'd recommend this hotel. The staff is very helpful in terms of providing information, making restaurant reservations, etc. Also the rooms are very large and clean.