If you're going to stay in Rome, stay at the Hotel Barberini. We booked 2 rooms for 5 people for 2 nights. I can't say enough about the great service, the fantastic location, and the hotel itself. The rooms aren't huge (few are in Europe), but they were a lot larger than we expected. Very comfortable, and very well appointed.
We booked directly with the hotel. The communication was excellent, they faxed us with our confirmation within a few minutes. On arrival, our rooms were ready for us, even though we arrived in the late morning.
Breakfast was wonderful, a fine selection and as much as you could want. The views from the breakfast room were wonderful.
When we wanted to get tickets for the hop-on, hop-off bus, the front desk just reached down and had tickets for us to purchase. How easy is that?
The location is close to the Trevi Fountain, and easy walking distance to most everything else, or you can just get on the hop-on, hop-off and go anywhere.
Right around the corner from the Hard Rock Cafe, and just up the street from a wonderful English Pub. Many restaurants in the area where you can dine right out on the quaint little streets.
When we return to Rome, we will definitely stay at the Barbarini again!