I wanted a nice hotel to cap off the holiday of a lifetime - and found it at Dei Mellini! Lovely rooms, very helpful staff, delicious breakfast, and well located. I've nothing to compare it with, but would think it's well enough away from the crowds while being fairly central. Air conditioning works well also! Superior hotel indeed.

This was our first trip to Rome so my husband and I researched the web and TripAdvisor for advice.
We only had a long weekend stay in Rome and knew we wanted to see as much as possible and would be walking most of the time. The Dei Mellini (which we found on Expedia) was the perfect choice for us. The location of the hotel gives you access to just about anything you might need: bus, restaurants (ask for directions to the Osteria/Gustos), pharmacy, pizzeria, etc. but you are not right in the hustle and bustle of the nighttime activities. We walked back to the hotel after midnight a couple of times and felt safe. The staff gave us a great map and will help in any way. Our very clean room was on the 6th floor and the bedroom window opened to the courtyard below, which we kept open all night because the weather was so pleasant without being disturbed by traffic whatsoever. Terrific bed, beautiful new bathroom and not cramped at all. We felt we had plenty of space. Very clean. There is a great view from the terrace which was off the 6th floor but it does close about 10pm. The breakfast buffet was a delight and the wait staff was very friendly and attentive.
We just happened to arrive at the airport as President Bush was arriving at the Vatican so we took a taxi because this would be the fastest. (Use only the white taxis, they are regulated.) It turned out to be the best choice and we would advise asking the front desk to arrange for a taxi or limo (which turned out to be just a nice large car) for your return trip to the airport, about 50 Eruos and 30 minutes. Beautiful city and beautiful hotel!!