I stayed at the Holiday Inn Rome West for three nights in October as part of a business meeting. This was my first trip to Rome (and Italy), and it was disappointing to be staying at this hotel so far from the city. It would have been great to be able to walk around the city a bit in between my meetings, but this hotel is a 30+ minute and 20 Euro drive (don't let the kms fool you - the traffic is amazing! it took us an hour to get in for dinner on a Thursday night!) If you're staying there to sightseeing, any money you save by staying at a hotel outside the city would easily be asborbed by taxi fare. The hotel does have a shuttle, but in order to maximize my very limited time for sightseeing, I didn't really have enough time to wait for the next run.
The hotel itself was OK - 1970's decor, but clean. The staff wasn't not very friendly, but I found that to be the case throughout Rome. There is a flatscreen tv in the room (and some sort of steamer thing), but you have to request an iron and ironing board. They have 3 computers in the lobby that you can pay to use the internet, and then wireless in the rooms. Bed was very stiff and linens not very comfortable. At this stage, I guess I'm used to staying in nicer hotels.
The hotel is located next to a major road, and there's a McDonalds within walking distance and perhaps a grocery store (not much!). While I did feel safe within the hotel, I would not (especially as a single woman) walk around the hotel property at night. We noticed a number of "women of the night" hanging out around the hotel as we arrived back after dinner each night. Not interested in seeing that side of Rome!
There were a bunch of tour groups staying at the hotel, and I suppose it's a decent place for a last stop before heading to the airport (which was only 30 min away).
I will not choose to stay here again, but if it's a business meeting and I have to, it would be OK.