Rome was the second stop on my fiancée and my trip to Europe last year. She did some advanced research for each city to figure out how to travel safely, comfortably and also stay inside our budget. Relais 6 was the answer for our Roman leg.
We live in Montreal, Canada, so I'm going to use our own city as a reference here. Like Rome, Montreal has a subway system (called the Metro(politain) like in Paris). Staying at Relais 6 is like staying in NDG (Notre-Dame-de-Grace) in Montreal. It's slightly outside of the main city, but connected by the subway. In fact, the Relais 6 is only about a 5 minute walk from the subway station. So at Relais 6 you can experience the benefits of staying at a VERY nice hotel for MUCH less than in the city centre, and you are still only about 15-20 minutes from wherever you want to go in Central Rome! For example, we left our room at 8:30 AM and were looking at the Coliseum by 8:50!
**Bonus: the subway station near Relais 6 is VERY clean and devoid of the gypsies that hustle you near the token machines in other subway stations throughout Rome. I recommend getting your tickets here for your return trip as well (or just get a day pass!)**
As I hinted earlier, the hotel is VERY nice. Not the largest of rooms, but very, very clean and a decent bathroom as well. The buffet breakfast is great, and the terrace in the back is very relaxing. The terrace was open for use at breakfast AND at night. Both nights we stayed at Relais 6 we were sipping on wine enjoying the night air. Just in back of the terrace is a World War 1/2 museum. Apparently the owner of Relais 6 is a collector, so if you are interested in such things, you may be able to browse his collection. We didn't visit ourselves, but it did look very interesting!
The staff were friendly and helpful. There was an error on our room bill that was simply and easily resolved with no stress. Nothing can ruin the start of your day like having to argue about something like money whilst dealing with a language barrier! However all was clarified very quickly and cordially (there was a charge from another room ... the numbers were inverted. Simple fix.)
Should my fiancée and I return to Rome (we didn't stay nearly long enough to see half of the things we meant to, so we quite possibly will) I am positive we will stay here again. It was that convenient and that good.