We found this on Tablet Hotels and loved this charming boutique hotel right near the Spanish Steps. For a room in Rome, we heard this was very spacious and comfortable and they were right. Our room was gorgeous with a modern, contemporary design. Full bathroom with tub and shower. Lots of space. Great view of the cobblestone streets below. A few blocks from the crowd at the Piazza de Spagna but close enough to walk. Right in the plush Via Condotti shopping area near all the big designers. The hotel staff was helpful in directing us around town, calling taxis, getting us a rental car. I would definitely stay here again (or at one of the sister properties, Babuino or Margutta)
We booked the Junior Suite via TabletHotels.com and loved it!
Also recommend letting the hotel book you a driver from the airport.