My wife and I have just come back from 4 nights in Rome without the kids (yay) and for the first 2 nights stayed in a perfectly good hotel called the 'Hotel Bright' in an area called Prenestina which is on the outskirts of the city. It's a perfectly nice enough hotel but almost 1 a hour journey each way on public transport from the Termini station. We were staying over the 1st of May holiday weekend and found accommodation hard to come by on the internet (and City centre hotels can be very pricey) so we booked the Bright on the fly. We found the interior and exterior to be clean and modern, the room we had was small but recently decorated and priced accordingly at 65E with breakfast, and it was quiet. The staff are helpful enough and we would definately recommend this hotel as the area seems safe enough but as said it's sited quite a distance from the city so if you need to use public transport to get into the city then be prepared to allow up to a hour for travelling as you'll have to take a bus then Metro to get to Termini station. The hotel is set back off a fairly busy road next to a car showroom garage with a Decathlon store on one side and a cafe / restaurant on the other and resembles a Travel Lodge sort of hotel, but don't let this put you off becasue if you are travelling through this hotel is quite clean and pleasant enough.