My girlfriend and I spent one night at Hotel Amitrano in September, arriving late in the evening after fun and games with the Circumvesuviana train from Naples (note: the Santuarini station is the one labelled as just 'Pompei' on the Circumvesuviana line; if you get off at Pompei Scavi you face a long walk). The surrounding streets don't feel the most secure; it did not take us long to realise why so many visitors take day trips to the city and not stay the night (although this isn't strictly the fault of the hotel, and was probably one of the better looking places in the area).
We were shown to our room on the second floor, although the receptionist seemed extremely eager to get away and did not offer us details of when breakfast was served, check out time etc (and the hotel was unable to give or show me a map of the city, despite being able to see several guidebooks on the other side of the reception desk). The room itself was adequate and the bed comfortable (being in a 'deluxe' room which did offer a balcony but on to a rather horrible side street).
Breakfast the next morning was unfortunately less than enjoyable, with croissants dry and the coffee providing a somewhat bitter aftertaste. To their credit however the service was friendly and an effort was being made, but by the time bread and meat was brought to our table we decided to not venture any further and so got up and went back to our room (I'm not sure if they would have kept bringing things out!).
We were able to leave our luggage with them behind reception for the day following our check out which was useful. Card payment was not accepted however, which was a little frustrating and unusual we thought for a large hotel with a similarly sizeable restaurant on the ground floor.
All in all, this did what we needed and gave us a good night's sleep, but we shall not be returning to the hotel (or probably the city) for an overnight stay again. It is a shame as the place should have so much potential with the simply stunning ancient ruins around the corner. In the future we will stay in Sorrento or nearby and travel into the city for the day.
This review is the subjective opinion of a TripAdvisor member and not of TripAdvisor LLC.