Just got back from a 3 night trip to Madrid, Spain staying at the Hotel Regina. The location is right next to the Metro which was nice and easy to get to the airport. It's also close distance to all the restaurants, bars and shopping. We got the standard double-twin room which was plenty big and had a nice size bathroom. It was very clean and located at the back side of the hotel which was nice considering we had no street noise. We didn't eat the breakfast buffet but it looked quite nice. I'd recommend heading to the Mercado de San Miguel which is about a 15 minute walk if you take a right out of the hotel just past Plaza Mayor.