We booked this hotel as a package for a great price.
It is a bit further out but is literally by a u ban station. You have to go only 5 stops to alexanderplatz. From there you can walk to all of the museums and great flow markets.
The district is lovely- opposit, and about a 5 min walk brings you to a street of bars and restaurant, cheaper than central berlin and great atmosphere.
Staff were very helpful and googled questions we had about trips we had booked and gave us weather updates.
Rooms were a bit small and warm, but realy who spends that much time in them.
Overall a bit further out than some, but fine with transport connections.