On my recent trip to Germany and the Czech Republic stayed here at the beginning of the trip and again at the end of the trip in June 2013. Loved this hotel, was in a super location as many others have stated and right beside the U Subway and S trains, also the Streetcars are available right on the other side of the train station and is one stop from the Main Berlin HBF station.
The rooms are larger and I had expected in Europe based on previous trips, very comfortable and quiet. Room was very clean. Beds are comfortable as well and they have a pillow menu. All of the staff that I came in contact with were very friendly and helpful.
Taxi from the airport to hotel was 18 euro in each direction. The only recommendations I have is if you chose this hotel and like breakfast, make sure it is included in your room rate, otherwise it is 24 euro per person per day. WIFI is also about 14 euro per day which is steep in my opinion.