Casa Alebrijes is new and there is a lot of attention to detail. Owner John is American but knows Guadalajara, and the hotel is very close to all the gay nightlife. It's also just a few blocks from the Centro for touring the historical area.
In addition to being clean fresh and new, with great beds, Casa Alejbrijes offers uniquely designed rooms, some with sitting areas and jacuzzis. There's an open courtyard in the building, hacienda style, where guests can meet and greet in front of a large fountain decorated with masks. The rooms are decorated with "Alebrijes" --cute little wooden toys handmade in Mexico.
There are nice LCD TVs with DVD players in each room, and great internet service, also guest computers. The owner could not be nicer! The large rooms offer a great value.
If you haven't been out in Guadalajara and you're gay, you need to go! It's a lot of fun, with dozens of gaybars, nightclubs and other types of venues (internet cafes, shops, sauna) to choose from.