Biking from Santa Fe to the Pacific coast

HI, I'm planning to ride my bike from the Caribbean to the Pacific, starting at some beach north from Santa Fe and finishing at either Santa Catalina or some at beach at Peninsula de Azuero.

Looking at the map, it seems that the road that connects Santa Fe to the Pacific Coast is cut, so I don't know how easy is to reach the Pacific coast from Santa Fe?

Are the roads that connect Santa Fe to Santiago, and then Santiago to either Santa Catalina or the south of Peninsula de Azuero bike friendly? Are there many heavy trucks on those roads?

Do you think is possible to get in the bus between Santiago and Santa Fe with my bike? or does the bus has a compartment where I can put it?

Thanks a lot