I've done this drive a bunch of times, and am from Ohio, right along your route, so I know it fairly well. There aren't exactly a ton of tourist destinations along the way, but here are a few suggestions:
Cleveland - it's not as bad as people say (well, it is, but there are still cool spots)
Cedar Point - Sandusky, Ohio. If you like roller coasters, this is the best park in the world (though it's not open year-round).
If you are into Hall of Fame stops, this is the perfect route. You can visit the basketball hall of fame (Springfield, MA), baseball hall of fame (Cooperstown, NY), the rock 'n roll hall of fame (Cleveland, OH), the pro football hall of fame (Canton, OH), and the college football hall of fame (South Bend, IN).
Another option is to take a slightly longer route, drive through Canada, and stop in Toronto, which is a pretty cool city. This is probably not the best idea if you are doing this trip in the winter. If you are going in the winter, I'd drive through CT and take 80 instead of 90, so you avoid Western NY, which can get really snowy.
Enjoy the trip!