Rt. 219 is a beautiful, but very-very rugged drive. You'd be on it all day, and while you pass some beautiful parts of our state (Lewisburg, Watoga, Marlinton, etc.), my advice would be to head up 19 and see the New River Gorge and the Bridge.
If you've already been on 19, have seen the New River Bridge, and are looking for something different, 219 to Elkins and Rt 33 back to Interstate 79 is a very beautiful and unique drive, but very time consuming. If you decide to go that way, here are some interesting places along the route, or just off of 219:
- Organ Cave: http://www.organcave.com/
- Greenbrier Resort: http://www.greenbrier.com/
- Droop Mountain Civil War Battlefield: http://www.droopmountainbattlefield.com/
- Cass Scenic Railroad: http://www.cassrailroad.com/
- Snowshoe Ski Resort: http://www.snowshoemtn.com/index.htm
- Greenbank National Radio Observatory: http://www.gb.nrao.edu/
- Edray Fish Hatchery: www.wchstv.com/traveling/2010/twv101007.shtml
- Historic Elkins: http://www.cityofelkinswv.com/
- Buckhannon: http://www.buckhannonwv.org/Welcome.html
Plenty of quaint Bed & Breakfasts along the way, local arts and crafts, and some local dining. Especially in Lewisburg, Elkins, and Buckhannon.
Good luck, and enjoy your visit.