I personally like the Holiday Inn / HI Express Chain. ihg.com/priorityclub/hotels/us/en/reservation
It has been several years, but I stayed at the HIE in Meadville which is half way between Erie and Pittsburgh on I-79. As I recall it was nice, clean, and safe area. (HIE's have free breakfast too.) ihg.com/priorityclub/…hoteldetail
It appears this is only three and a half hours from Toronto. If you would like to drive 5 hours each day, perhaps shoot for south of Pittsburgh?
Here is a Candlewood Suites in Washington, PA which is ~ 5 hours 13 minutes from Toronto. ihg.com/priorityclub/…hoteldetail I have not stayed here, but is is part of the same Holiday Inn hotel group.
From Washington, PA, it is another 5 hours 18 minutes to this HIE in Mt. Airy, NC: ihg.com/priorityclub/…hoteldetail I stayed here last summer and although we had an issue with housekeeping, the hotel was nice and safe.
It's another 4 hours 22 minutes to Myrtle Beach from Mt Airy. (Or add a few hours if you are in heavy traffic.)
Are you looking for activities to do each day along the way?
In Erie, http://www.waldameer.com/ is a clean and fun family amusement park.
And near Mount Airy are two beautiful state parks: Pilot Mountain and Hanging Rock. www.ncparks.gov/Visit/parks/pimo/main.php www.ncparks.gov/Visit/parks/haro/main.php
Here is a google map link for the hotel stops: http://goo.gl/maps/AxVFq
Edited: 10:36 pm, April 07, 2013