In Scranton PA (right off I-81), you could take the interesting coal mine tour.
In Elmira, NY (right off NY17/I86), you can take a glider ride at Harris Hill (great views and exhilarating experience).
In Corning (the next city west of the interstate), you can visit the Glass Museum - really interesting and fun. There are also good dining options nearby on Market St. and good lodging options as well.
If you don't mind venturing off the interstate, Watkins Glen (20 miles from Corning on NY414) is a great option to visit Watkins Glen State Park - there is an amazing gorge w/many waterfalls. It is about a 1.5 mile hike each way.
From there, you could go up the west side of Seneca Lake (NY 14) to NY 54 (Penn Yan). Continuing on NY 54 takes you right to Bath. On NY 14 and 54, there are MANY wineries. I am not a wine drinker so I can't recommend any specific ones, but there are some well regarded ones (based on recommendations from other TA posters - search on "Finger Lakes" then "attractions" or "wineries"). Glenora winery has a good restaurant. This drive is also scenic as you drive along Seneca then Keuka lakes.
The Curtiss museum just outside of Bath is interesting; especially if you enjoy aviation. Either way, it's worth a look.