Vacation rental or condo stay

When I travel on vacation I like to stay not in hotels but use vacation rentals. I checked few webistes for holiday rentals, but I love to get as many input as possibly. Can any one help as to rentals in this area and near to St Louis?. Or does any one have any referrences as to where they may have stayed? This trip is for the Grils 50+ so it will have to be a safe area.