Are you thinking of doing this as a day trip from Pismo?
IF you were planning on taking Highway 1 up to Carmel from Pismo Beach, that's close to a 4 hour drive WITHOUT stops. I wouldn't do it JUST to do the 17 Mile Drive.
Besides.... There's MUCH better scenery to spend your time in than that!!
Point Lobos State Reserve, which is a few miles south of Carmel, offers stunning coastal scenery from several easy to walk hiking trails.
I really don't consider Monterey/Carmel day trip material. I DO consider it one of the most romantic areas to spend a honeymoon in. I suggest giving up a night or two from Pismo and spend them in Carmel or Pacific Grove and enjoy romantic walks on Carmel Beach, hike Point Lobos, drive the 17 Mile Drive, walk the scenic rec trail in Pacific Grove.
IF you choose to do this as a day trip, be aware that you're looking at a minimum of 8 hours WITHOUT stops just getting there & back. You could opt for driving UP Highway 1 to Monterey/Carmel and then return by the quicker Highway 68 to Salinas and taking Highway 101 back to Pismo.