If you drive into the city, parking can be a hassle, to say the least. You can take the interstate 280 to Daly City and take the BART from there. OR You can park in various pay lots by Fisherman's Wharf. If you take BART, you could get off at the embarcadero and take a cab over to Fisherman's wharf, or get off at Powell and take the cable car. Food in the city is fabulous. One of my fav things to do is just get bread bowl clam chowder near fisherman's wharf from one of the street counter places. There are vegetarian restaruants too that are in the city. Pacific Cafe is great for Seafood.

As far as going to Napa for wine tasting, I would go to the Santa CRuz mountain wineries instead if you are staying in Cuppertino. Some of my Favorites are Thomas Fogerty and J Lohr. Check out their websites and check out www.scmwa.com (santa cruz mountain wine assoc)

If you insist on going to Napa or Sonoma, and the mud baths, you probably will want to stay in Callistoga at the Comfort inn, it's very near the mud baths. Driving from Cupertino to Napa/Sonoma is do-able just not while drinking! There are many fabulous wineries all over in both Napa and Sonoma. The Domaine Chandon tour is great. Napa and Sonoma wineries all charge for tasting, as do alot of the Santa Cruz wineries. Santa Cruz and the Monterey bay aquarium, Cannry row, Carmel, are must sees in my opinion..And the traffic is not as bad out that way compared to getting to Napa..just an opinion!

Thanks for the info about the Santa Cruz winery area. I had no idea they were even there.