It should be perfectlly safe. This is a recently developed low-rise office building neighborhood, except for a couple of new townhouse developments, and quite deserted at night -- although there is a multiplex movie theatre not too far down Eisenhower Avenue toward the center of town. As always, be alert, but you shouldn't have any trouble -- except for possible traffic noise from the nearby I-95/495 (Capital Beltway), depending on how well insulated the rooms are and which way yours faces. You might consider asking for one facing the other way, which might even have a nice view of the National Masonic Memorial to George Washington (worth visiting).
Another benefit of staying near the Eisenhower Metro is that it's the terminus of the Yellow Line, so even if you go to downtown DC in the rush hour you're sure to get a seat.
Enjoy your visit.