To mlgb, yes I run a B&B in Huarocondo (not quite Cusco) and the reason I recommended the Bus in this instance is because of Silke G's statement
'I like to get a real sense of a place when I travel and not only do tourist things. I like nature scenery and am quite adventurous.'
To get a real sense of a place, take the bus. To save time, take a plane.
My purpose for being on these forums is not to drum up business, It is to provide my opinions and first hand information, from someone living in the region, to those who have questions or are looking for advice. I made two trips to Cusco prior to moving here and have traveled the area by plane, bus, and car all of which have their benefits and drawbacks. All of my opinions are based on my experience and information available at the time, not my B&B. So please do not challenge my motives.
To Silke G, those will be two one way flights and will cost you more than a round trip from Lima to Cusco. I did a quick search for airfare, assuming a 1 weak trip, from May 4 to May 11 for two adults. Round trip from Lima to Cusco on Star Peru would run $343.54 total for 2. If you take 2 one way flights, Lima to Arequipa on Taca came up at $309.00 for two and the Cusco to Lima leg is $353.10 for two on Taca. You may save a little time, but it may also cost you double in airfare, Just one more thing to consider.