Between Fresno and the parks there are only a few B&Bs and a couple of small old motels in Reedley.
I'd suggest if you want to enter from 180 check the airport area in Fresno, that is right off 180 on the east side of the city. Hotels include Courtyard by Marriott, Holiday Inn, and Picadilly Inn.
Bed and Breakfasts along the way are basically listed here
That list also includes Wonder Valley, a dude ranch type set up. That might be a possibility.
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