We spent 4 nights in this hotel, not cheap to say the least. Good location but the breakfast was really disappointing and the room was noisy. The air con didn't work either... Room was clean though and the staff were friendly.

This is an odd, contemporary, hotel. The pros: location, staff are helpful, The cons: lighting, American television stations were almost nonexistent, internet was spotty at best, complimentary breakfast is suffient but nothing to boast about, furnishings are of thrift store quality and the bed lacks any luxury Although i wouldn't recommend this hotel for amenities, I would recommend this hotel... More

Pluses: Location of this hotel is good - within a walking distance from Vatican, Castel Sant-Angelo... The interior decoration is modern with clin d'oeil to modern art - our portion of the 3rd floor had a wall dedicated to Miles Davis. The rooms are spacious and impeccably clean. The bathroom is elegantly designed and very practical. The breakfast buffet is... More

The hotel is a pretty nice hotel with some unusually angled rooms, the architect must have been very busy laying out the design.Some of the best features of this hotel are the reception staff and the people who cleaned the rooms.These guys who manned reception could not have been more genuinely friendly and helpful.The cost of the rooms was not... More

Hotel twenty one is well situated for all attractions , we walked to all of them including the Vatican and the colosseum , there is a nice bar at the end of the road "little devil". Rooms we lovely paid a bit more and got a suite it was superb

My wife and I spent a long anniversary weekend at Hotel Twentyone. Though our time was limited mostly to sleeping, we did enjoy our stay in a junior suite. Positives: -- Great location -- Very friendly and nice staff, including at the bar -- Breakfast bar, while a bit generic, was plentiful, tasty and (at least for me) always had... More

i book a jr suite for my honeymoon and we love it. we remain there for 5 days and every day we use jacuzzy, with elegant circular for therest is in a very good area with metro close by. room are not so big but clean.. romantic ambience is evenly supplemented with all the modern amenities to make a couple’s... More

my and my friends stayed here for 6 days. it's close to metro station and walking distance to all. modern hotel with excelent staff. rooms are not big but beautifull. wifi connection is ok. we like a lot the deluxe rooms with a balcony. breakfast is good.

Just spent a 4 day Easter weekend at the Twenty One hotel on Via Cola de Rienzo. My experience of Italian hotels to date in Rome and Milan has been average at best, so my expectations were low. However for the moment we checked in, the staff were helpful and happy, not overbearing, just natural. Same with restaurant and bar... More