I highly recommend Quinta Las Acacias. If you don't mind spending a few extra pesos, this oasis in Guanajuato is one of the best hotels I've ever had the pleasure of staying at. The staff, restaurant, room, service--all are top notch. From the day I reserved my room to the day I left, I had an excellent experience. The restaurant is one of the best in the city. The key staff are attentive, bilingual, and courteous. The room was amazing.
Some observations. The cost may be prohibitive, however, I negotiated a lower price with the mgt, since I was staying for an extended period. The hotel is located on the edge of town, and away from the noise of downtown, but this means a good 25 minute walk to the center, and another such walk, if you do not take a cab (not expensive) to return, and the return walk is mostly uphill. From the street to my room was 70 steps (no elevators), so not for those for whom a vigorous walk is a challenge--add that to the nearly 7,000 ft. altitude and you'll... more