A weekend in this charming and scenic town, situated halfway between San Francisco and Los Angeles and nestled in the Santa Lucia Mountain Range, can be whatever you want it to be: a relaxing getaway or a buzz of activity. For serenity, pack a lunch and head north or south to picnic at one of the dozens of picturesque wineries. Head west for great beaches, perfect for a leisurely swim. For a dose of history, visit the birthplace and heart of this quaint town: the beautiful adobe-brick Mission San Luis Obispo. Children will revel in the plentiful fun activities, such as the Charles Paddock Zoo, the Morro Bay Aquarium and the Children's Museum. For a laugh or a gasp, stop in at the outrageously decorated Madonna Inn, where nothing in the garish décor is consistent except for an abundance of the color pink. All are welcome for a peek inside the lobby's men's room for more interior design surprises.  More info